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KMID : 0921620150450010044
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Journal of Bacteriology and Virology
2015 Volume.45 No. 1 p.44 ~ p.50
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Intranasal Administration Model for Evaluating Protection Against Influenza Virus in Mice
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Choi Soo-Won
Youn Ha-Na
Hong Woo-Tack
Park Jae-Keun
Yuk Seong-Su
Kwon Jung-Hoon
Noh Jin-Yong
Kang Jung-Sun
Ryu Jeoung-Jin
Lee Joong-Bok
Park Seung-Yong
Choi In-Soo
Lee Sang-Won
Song Chang-Seon
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Abstract
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Antiviral activity against Influenza virus of 14 Lactobacillus species isolated from food was monitored. Lactobacillus species were isolated from traditional Korean fermented food. Each live Lactobacillus was administered into the nasal cavity of SPF 6-week-old BALB/c mice. After the Lactobacillus treatment, Influenza virus (A/NWS/33/H1N1) was inoculated to each mouse. Clinical signs and mortality was monitored for 21 days. Each Lactobacillus strain showed various level of antiviral activity against Influenza virus. As a result of this study, this mouse experiment model, including intranasal treatment of live Lactobacillus species, could be effective model in evaluating immunomodulatory response of probiotics against respiratory viruses.
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KEYWORD
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Animal model, Probiotics, Influenza, Antiviral
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